Epidermal Repair

Corneotherapy implications and the reduction of excessive transepidermal water loss by Darlene McCord, Ph.D

Preventive corneotherapy , A term coined in the 1990s by Albert Kligman, MD, Ph.D., became one of the most important principles of treatment technologies skin care. The purpose corneotherapy topical administration of active concentrates through the skin, homeostasis of the skin barrier. The last search development in the understanding of the stratum corneum is corneotherapy, focusing on correcting the defective horny layer treatment.

M. Kligman, corneobiologist, explains: "When you see the inflamed skin, regardless of the cause, the stratum corneum is not waterproof and breathable. But if the repair layer cornea that tells the underlying tissues that do not have to keep reacting as if there was a danger to the environment. "Peter Elias, MD, the leader corneobiologist world, also passed this off-on therapy, according to Kligman.

"Lifelong distinct outer layer of the epidermis and desquamation are ordered to correct the barrier function has been fulfilled by the stratum corneum "According Haftek Marek, MD, Ph.D. The primary function of the epidermis is the production the stratum corneum. The epidermis and dermis, both the immune system. The epidermis and the immune response to a stratum corneum disruption related to the role of barrier repair and regulation of insensible water loss (PIA).

PIE is controlled by the stratum corneum and is a normal part of cellular activity. PIE regulates the stratum corneum and helps prevent dehydration, keeping the average 2 to 5g/hr/cm2 cake. Excessive PIE (e-IPP) triggers an inflammatory response the epidermis and dermis and starts the repair process.

Many factors contribute to moisture, including e-PIE below 40%, changes in pH of the skin, normal aging and the alteration of the barrier. The correction can be e-PIE by the application of occlusive treatment and semi-permeable.

occlusive products remove the barrier recovery and reduce the epidermal proliferative response to an abnormal barrier coating layer. semipermeable or breathable barrier as Nurtrashield not slow recovery of the barrier and allow normal cellular respiration.

Completely occlusive therapy, such as petroleum jelly or mineral oil, inhibits the PIE. In doing so, without however, delayed the maturation of the epidermis and reduced the barrier repair. In addition, occlusion of the skin increases the risk of infection and decreases the protection the normal pH of skin can be reduced TEWL mantle.6 obtained with the occlusion, however, side effects of occlusion seem to outweigh its benefits.

Nutrashield is a semipermeable or breathable barrier that allows for normal epidermal proliferation and barrier repair. Nutrashield, when applied corneotherapy plan, reducing e-PIE and allow the normal repair process to take place. OlivamineTM and other special ingredients in Nutrashield, such as lipids, vitamins and antioxidants help in the repair process.

The repair process of the skin depends on good skin hydration achieved with normal TEWL. skin repair and decreasing the inflammation can be positively influenced by the use Nutrashield a semipermeable barrier to e-PIE.

About the Author

Dr. Darlene McCord is one of the two founders of McCord
Research. As senior researcher, she brings a unique blend of scientific
credentials to the position. Through her leadership, the company has achieved
worldwide recognition in the OTC Drug and Medical Device
categories. Her field of specialty is corneotherapy,
focusing on the transport of small molecules across the stratum corneum for
treatment of skin disorders associated with distressed and wounded skin. Darlene
McCord is widely published on subjects related to immunodermatology
and corneotherapy.

Dr. Darlene McCord is known for her work, as a biochemist, in skin and wound care. She has been awarded two patents and six medical devices in the field. She currently has more than 30 skin health products being sold around the world. Dr. Darlene McCord’s most current commercialized skin and wound care product offering is the Remedy brand distributed by Medline Industries. The line is based on a proprietary blend of small molecules called Olivamine ™ that provide corneotherapeutic support for diseased skin. Previously, Dr. Darlene McCord developed the Restore line for Hollister and the Cavalon line for 3M. She is currently working with the University of Iowa on compounds that may reverse early stages of necrosis and that can activate GO quiescent cells in the chronic wound environment.

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